Odette Yustman was born Odette Juliette Yustman in Los Angeles, California. Her mother, Lydia, is Cuban, and her father, Victor Yustman, who is of Italian and French descent, was born in Bogotá, Colombia and raised in Nicaragua. Annable is fluent in Spanish.
Odette Yustman graduated from Woodcrest Christian High School in Riverside, California. After graduating, she had planned on getting a degree in business finance at Loyola Marymount University before she decided to pursue a career in acting.